Educational Workshop: Contemporary Issues in Clinical Trials Methods

Friday, July 20, 2018
8 a.m. – 5 p.m.
Chicago, Illinois



This workshop will cover contemporary issues in clinical trials, which aid clinicians in selecting cost-effective trial designs. NEW THIS YEAR, the workshop will cover: 1) multiple comparisons, 2) Bayesian thinking, 3) estimands, and 4) trial simulation. Instructors from both industry and academia will present. For each topic, lectures will start with an overview of basic concepts, followed by more advanced topics, using practical examples. The targeted audience is clinicians and statisticians, and the aim is for clinicians to deepen conceptual understanding, as well as to provide statisticians with available resources.

This workshop is organized by the Clinical Trials Advancement and Methods Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART).

Program Chairs



  • Time
  • Topics

8 a.m.

Opening Remarks

8:10 – 9:40 a.m.

Multiple Comparisons
Steve Ruberg, Consultant

9:40 – 10 a.m.


10 – 11:30 a.m.

Bayesian Thinking
Steve Ruberg, Consultant

11:30 a.m. – 12:30 p.m.

Lunch (included)

12:30 – 2 p.m.

Estimands [55 minutes]
Steve Ruberg, Consultant (10 minutes)
Fabian Model, Roche (45 minutes)

Panel Discussion: Clinical Trials Implications and FDA Perspectives [35 minutes]
Paul Aisen, University of Southern California
Billy Dunn, U.S. Food & Drug Administration
Hong Liu-Seifert, Eli Lilly and Company
Fabian Model, Roche
Steve Ruberg, Consultant

2 – 3 p.m.

AD Trial Simulation Concepts
Michael Donohue, University of Southern California

3 – 3:20 p.m.


3:20 – 4:20 p.m.

Simulation in Generation Study
Angelica Caputo, Novartis

4:20 – 4:50 p.m.


4:50 p.m.

Closing Remarks

Target Audience

Clinicians and statisticians.


Educational workshops require a separate registration fee in addition to AAIC full conference registration, or may be purchased as a stand-alone event. Registration is open.


ISTAART logoThe Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) is a professional society for individuals interested in Alzheimer's and dementia science — including scientists, physicians and other professionals involved in the causes and treatments of Alzheimer's disease and other dementias. ISTAART membership makes AAIC even better: receive discounted registration, participate in professional interest areas (PIA), attend PIA Day scientific sessions (Saturday, July 21) and attend exclusive member-only scientific and networking events. Members also receive ongoing benefits throughout the year, including an online monthly subscription to Alzheimer's & Dementia: The Journal of the Alzheimer's Association, free online access to Neurobiology of Aging, access to the online career center, monthly e-newsletters, networking forums and extended LOI deadlines for the Alzheimer's Association International Research Grant Program.

Non-members are encouraged to learn more and join ISTAART. Non-members may also join ISTAART during AAIC registration — select "Member +PLUS" or "Student Member +PLUS" as the AAIC registration category to purchase one year of ISTAART membership in addition to AAIC registration at the member rate. Available to new members only.


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