Alzheimer's Assocation Research only
All of
  • Go to
  • Research Center
  • AAIC
  • Journal
  • Grants
  • TrialMatch
  • Press
  • Donate
  • Contact Us
Science and Progress
Clinical Trials
Funding and Collaboration
You can Help
Stay Current
Video and Resources

Text Size

Small text Medium text Large text

Research Grants 2006

To view an abstract, select an author from the vertical list on the left.

2006 Grant - Cattaneo

Recombinant Antibodies Against A-beta Oligomers: In Vivo Targeting and Delivery

Antonino Cattaneo, Ph.D.
European Brain Research Institute
Rome, Italy

2006 Investigator-Initiated Research Grant

Beta-amyloid protein fragments, key suspects in Alzheimer pathology, assemble themselves into tiny clusters called oligomers, which form larger structures. Subsequent stages of assembly continue, eventually forming a well-characterized feature of Alzheimer's disease, the amyloid plaque.

Recent studies have shown that one or more oligomeric forms of beta-amyloid may be the real culprits of Alzheimer's disease and that these structures may play a key role in disrupting cell-to-cell communication in the brain. Consequently, beta-amyloid oligomers are a target of particular interest for developing diagnostic tools and new therapies.

Antonino Cattaneo, Ph.D., and colleagues are studying a number of specialized antibodies that may function as molecular probes capable of selecting only beta-amyloid oligomers-rather than single beta-amyloid molecules or larger beta-amyloid-based structures. In their experimental system, the antibodies will be delivered to specific cellular compartments in neurons that play a role in sending or receiving messages. This strategy may help them characterize when, where and how oligomers are formed and how they exert a toxic effect.

The researchers will also test the most promising antibody candidates in genetically altered mice that develop an Alzheimer-like disorder. The outcome of this work may answer questions about beta-amyloid's toxic effect and suggest strategies for future drug development studies.

Alzheimer's Association International Conference | July 16-20, 2017, London, England

Abstract Submissions Now Open

The Scientific Program Committee is now accepting submissions for poster
presentations, oral presentations and featured research sessions.