Alzheimer's Assocation Research only
All of
  • Go to
  • Research Center
  • AAIC
  • Journal
  • Grants
  • TrialMatch
  • Press
  • Donate
  • Contact Us
Science and Progress
Clinical Trials
Funding and Collaboration
You can Help
Stay Current
Video and Resources

Text Size

Small text Medium text Large text

Research Grants 2009

To view an abstract, select an author from the vertical list on the left.

2009 Grants - Manning-Bog

The Role of DJ-1 in Cognitive Impairment

Amy B. Manning-Bog, Ph.D.
The Parkinson's Institute
Sunnyvale, California

2009 New Investigator Research Grant

A high percentage of individuals affected by Parkinson's disease will eventually develop dementia; and many individuals with Alzheimer's dementia exhibit some symptoms resembling Parkinson's disease. These observations suggest that the two conditions may be associated with overlapping pathologies in the brain.

DJ-1 is a gene that codes for a protein found in many cells, and mutations of the DJ-1 gene are associated with some inherited forms of Parkinson's disease. Amy B. Manning-Bog, Ph.D. and colleagues are studying the role of the DJ-1 gene in Parkinson's disease and dementia. Using mice that were genetically altered so that the DJ-1 gene is not expressed, Dr. Manning-Bog's team has shown that lack of a functional DJ-1 gene can lead to cognitive impairment and development of some Alzheimer-like pathologies in the brain. The researchers now plan to perform a detailed analysis of the role of DJ-1 and how its absence leads to a brain condition exhibiting features of both Parkinson's disease and Alzheimer's disease. These studies could help to characterize one of the fundamental genetic defects leading to dementia.

Alzheimer's Association International Conference | July 16-20, 2017, London, England

Abstract Submissions Now Open

The Scientific Program Committee is now accepting submissions for poster
presentations, oral presentations and featured research sessions.