Alzheimer's Assocation Research only
All of
  • Go to
  • Research Center
  • AAIC
  • Journal
  • Grants
  • TrialMatch
  • Press
  • Donate
  • Contact Us
Science and Progress
Clinical Trials
Funding and Collaboration
You can Help
Stay Current
Video and Resources

Text Size

Small text Medium text Large text

Research Grants 2012

To view an abstract, select an author from the vertical list on the left.

2012 Grants - Vertivel

Proteomic Analysis of Gamma-Secretase Residing in Raft Domains

Kulandaivelu S. Vetrivel, Ph.D.
The University of Chicago
Chicago, Illinois

2012 New Investigator Research Grant

Gamma-secretase is a key molecule in Alzheimer’s disease. It is one of two main protein complexes in the biochemical pathway that produces beta-amyloid, a protein fragment that can aggregate to form amyloid plaques in the brain. Because of this important role of gamma-secretase, scientists have worked to develop drugs to inhibit it. However, gamma-secretase has many other important functions, so inhibiting its function may have undesirable side effects.

In previous research, Kulandaivelu S. Vetrivel, Ph.D., and colleagues found that some copies of gamma-secretase inside cells are attached to small particles of fat-like molecules called lipid rafts. The researchers also found evidence that the production of beta-amyloid may occur at these lipid rafts, whereas other functions of gamma-secretase may be performed elsewhere.

Dr. Vetrivel and colleagues have proposed a series of studies to further characterize how gamma-secretase functions when attached to lipid rafts. They plan to use biochemical techniques to identify other proteins that work with gamma-secretase when it is in this specialized compartment. The researchers will then use gene manipulation to characterize how those proteins help gamma-secretase produce beta-amyloid. These studies will enhance our understanding of how beta-amyloid is produced, and they may help to identify new ways to inhibit gamma-secretase that have fewer side effects.

Alzheimer's Association International Conference | July 16-20, 2017, London, England

Abstract Submissions Now Open

The Scientific Program Committee is now accepting submissions for poster
presentations, oral presentations and featured research sessions.