To view an abstract, select an author from the vertical list on the left.
2013 Grants - Lee
Functional Studies of Phosphorylation Regulation in Alzheimer's Disease
Tae Ho Lee, Ph.D.
Beth Israel Deaconess Medical Center
2013 New Investigator Research Grant
The functions of nearly all cells, including nerve cells, are regulated by numerous signaling pathways. One of the most common ways that these pathways control cell function is by adding chemical phosphate groups to proteins (phosphorylation), thereby changing the way those proteins behave and function.
One protein thought to help protect nerve cells from decline in Alzheimer's disease is known as Pin1 (peptidyl-prolyl cis/trans isomerase, NIM interacting 1). Evidence suggests that inhibition of Pin1 may contribute to the development of Alzheimer's characteristics in the brain, such as amyloid plaques, neurofibrillary tangles and nerve cell death.
Tae Ho Lee, Ph.D. and colleagues have been studying Pin1 and its possible role in Alzheimer's disease. They have found that Pin1 is phosphorylated, and thereby inhibited, by another protein known as DAPK1 (death-associated protein kinase 1). They have proposed more extensive studies of Pin1 and DAPK1 to explore the role of these proteins in the development and progression of Alzheimer's disease. These studies will yield important new information about signaling pathways and their role in Alzheimer's disease, and they may lead to the identification of potential targets for drugs to slow or prevent disease progression.