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Research Grants 2015

To view an abstract, select an author from the vertical list on the left.

2015 Grants - Pasinetti

BDPP Treatment for Mild Cognitive Impairment and Prediabetes

Giulio Maria Pasinetti, M.D., Ph.D.
Icahn School of Medicine at Mount Sinai
New York, New York

2015 Part the Cloud Translational Research Funding for Alzheimer’s Disease

This Phase 1b clinical trial will examine the safety and tolerability of a combination treatment using three grape-derived compounds in people with very early stages of Alzheimer’s disease.

Mild cognitive impairment (MCI) is a condition in which an individual may have some memory decline but not enough to affect his or her ability to perform daily functions independently. Some but not all people who have MCI progress to Alzheimer’s disease. Diabetes and prediabetes (a condition in which blood sugar levels are higher than normal, but not considered to be diabetic) have been shown to increase risk for cognitive decline and the development of Alzheimer’s disease.

Giulio Maria Pasinetti, M.D., Ph.D., and colleagues will investigate the use of a dietary supplement called “Biologically Active Dietary Polyphenol Preparation” (BDPP) to help slow or prevent the development of Alzheimer’s in people with MCI and prediabetes. BDPP contains a mixture of polyphenols, a class of chemicals found in certain plants (e.g. grapes) that may support brain health. One example of a polyphenol is resveratrol, which is found in red wine and grape juice and is being studied for its potentially beneficial effects on the normal and diseased brain.

Dr. Pasinetti and colleagues will assess the safety, side effects and optimal dosing of BDPP and determine if BDPP can enter the brain. The researchers will measure the levels of BDPP as well as certain molecules linked to the progression of Alzheimer’s in cerebrospinal fluid (the fluid that surrounds the brain and spinal cord). They will also examine if BDPP treatment helps improve brain function. This study could pave the way for more extensive tests of BDPP as a way to slow, stop, or prevent the development of Alzheimer’s disease.

Alzheimer's Association International Conference | July 16-20, 2017, London, England

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