Alzheimer's Assocation Research only
All of alz.org
  • Go to Alz.org
  • Research Center
  • AAIC
  • ISTAART
  • Journal
  • Grants
  • TrialMatch
  • Press
  • Donate
  • Contact Us
Home
Science and Progress
Clinical Trials
Funding and Collaboration
You can Help
Stay Current
Video and Resources

Text Size

Small text Medium text Large text

Research Grants 2017


To view an abstract, select an author from the vertical list on the left.

2017 Grants - Gervais

Sleep, Cognition, and Inflammation Following Natural or Surgical Menopause

Nicole Gervais, Ph.D.
University of Toronto
Toronto, Canada

2017 Alzheimer’s Association Research Fellowship (AARF)

How does the loss of estrogen affect cognition in a high-risk Alzheimer’s population?

Background
Alzheimer’s disease disproportionately affects women and emerging evidence suggests there may be unique biological and lifestyle factors that underlie these differences. A woman’s brain health, for example, may be affected more strongly than a man’s by the presence of APOE-e4, a gene variant linked to Alzheimer’s risk. Moreover, hormonal changes in women, especially the loss of estrogen, can also impact brain function. Loss of estrogen due to natural or surgical menopause has been associated with sleep disruption, higher levels of brain inflammation and cognitive impairment. More research is needed to better understand the complex ways these factors may interact to promote Alzheimer’s risk.

Research Plan
Nicole Gervais, Ph.D., and colleagues will study how the loss of estrogen due to natural or surgical menopause affects sleep, cognitive function, brain inflammation and brain structure. Surgical menopause occurs when women have their ovaries removed before natural menopause. In this study, the women in the surgical menopause group had their ovaries removed to reduce the risk of cancer associated with carrying the BRCA gene. The surgical and natural menopause groups will include women with and without hormone replacement therapy. The researchers will determine how hormone levels relate to sleep quality and levels of inflammatory markers in the blood. The participants will undergo brain imaging to measure changes in areas known to be important for memory function. In addition, the researchers will examine if women who carry the APOE-e4 risk gene show more significant changes in sleep quality, levels of inflammation and cognitive function.

Impact
The results of this work could shed new light on how hormones and genetics may interact to promote Alzheimer’s risk, possibly through effects on sleep and brain inflammation. A better understanding of these biological mechanisms could suggest ways to reduce risk, or develop targeted treatments to slow or prevent Alzheimer’s disease.


Alzheimer's Association International Conference | July 16-20, 2017, London, England

Abstract Submissions Now Open

The Scientific Program Committee is now accepting submissions for poster
presentations, oral presentations and featured research sessions.